Xi He, Ph.D.
![](/-/media/legacy/legacy-and-pre-launch-image-edits/scholars/1997/xi-he.jpg?la=es&h=151&w=112&hash=0C809543D05FE4B4046251C0940B8B7C)
- Title
- Endowed Research Chair and ACS Research Professor
- Department
- F. M. Kirby Center
- Institution
- Boston Children's Hospital, Harvard University
- Address
-
CLS Building 12064
3 Blackfan Circle - City, State, ZIP
- Boston, MA 02115
- Phone
- (617) 919-2257
- [email protected]
- Website
- http://www.childrenshospital.org/researchers/xi-he
- Research field
- Developmental Biology
- Award year
- 1997
Research
We are interested in the signaling mechanisms by the Wnt family of secreted molecules. It has become clear that Wnt proteins are one of about half a dozen major families of conserved signaling proteins that guide embryonic development and adult homeostasis. We primarily focus on Wnt signaling in early vertebrate embryonic patterning, in cell polarity regulation (planar cell polarity and neuronal polarity), and in stem cell and cancer biology. We employ molecular, biochemical, embryological and genetic approaches in several experimental systems, including Xenopus embryos, mammalian and Drosophila cell cultures, and knockout mice. Our main projects are focused on: 1) Wnt/beta-catenin signaling 2) Wnt signaling in cell polarity 3) Wnt signaling in stem cell biology, cancer and diseases.
Scholar Keywords
1997 Search Pew Scholars
- Andrew Camilli, Ph.D.
- Ann Marie Craig, Ph.D.
- Patrick Dolph, Ph.D.
- Anirvan Ghosh, Ph.D.
- Benjamin S. Glick, Ph.D.
- Roberta A. Gottlieb, M.D.
- Gregory J. Hannon, Ph.D.
- Xi He, Ph.D.
- Ann B. Hill, Ph.D.
- Gokhan S. Hotamisligil, M.D., Ph.D.
- Gail P. Jarvik, M.D., Ph.D.
- Stephen L. Johnson, Ph.D.
- Maurice J. Kernan, Ph.D.
- Daniel S. Kessler, Ph.D.
- Michael R. Koelle, Ph.D.
- Kuo-Fen Lee, Ph.D.
- Tom W. Muir, Ph.D.
- William C. Sha, M.D., Ph.D.
- Kristiina Vuori, M.D., Ph.D.
- Wilma M. Wasco, Ph.D.
- Philip B. Wedegaertner, Ph.D.
- Yixian Zheng, Ph.D.