Gregory J. Hannon, Ph.D.
![](/-/media/legacy/legacy-and-pre-launch-image-edits/scholars/1997/gregory-hannon.jpg?la=es&h=329&w=264&hash=9E313609BB54D5D05D7640FDCC7383B9)
- Title
- Director
- Institution
- Cancer Research UK Cambridge Institute
- Address
- Li Ka Shing Centre, Box 278 Robinson Way
- City
- Cambridge CB2 0R2
- Country
- United Kingdom
- Phone
- 01223 769843
- [email protected]
- Website
- http://www.hannonlab.org/team/
- Research field
- Genetics
- Award year
- 1997
Research
The Hannon laboratory comprises a broad spectrum of programs in small RNA biology, mammalian genetics and genomics. We study RNAi and related pathways in a wide variety of organisms to extract common themes that define both the mechanisms by which small RNAs act and the biological processes which they impact. Currently, we focus on microRNAs, endogenous siRNAs and piRNAs and their roles in gene regulation, cancer biology, stem cell biology and in defense of the genome against transposons. We develop genome-wide shRNA tools for RNAi-based genetics in mammalian cells, and we are now producing similar collections of artificial microRNAs for Arabidopsis. Our genomic efforts include the application of RNAi-based genetic screens to cancer biology and stem cells. We also make heavy use of next generation sequencing methodologies for probing small RNA populations, in part as a member of the ENCODE consortium. Finally, we develop and apply focal re-sequencing methods for identifying disease relevant mutations, for probing the epigenetic landscape and for the study of human evolution.
Scholar Keywords
1997 Search Pew Scholars
- Andrew Camilli, Ph.D.
- Ann Marie Craig, Ph.D.
- Patrick Dolph, Ph.D.
- Anirvan Ghosh, Ph.D.
- Benjamin S. Glick, Ph.D.
- Roberta A. Gottlieb, M.D.
- Gregory J. Hannon, Ph.D.
- Xi He, Ph.D.
- Ann B. Hill, Ph.D.
- Gokhan S. Hotamisligil, M.D., Ph.D.
- Gail P. Jarvik, M.D., Ph.D.
- Stephen L. Johnson, Ph.D.
- Maurice J. Kernan, Ph.D.
- Daniel S. Kessler, Ph.D.
- Michael R. Koelle, Ph.D.
- Kuo-Fen Lee, Ph.D.
- Tom W. Muir, Ph.D.
- William C. Sha, M.D., Ph.D.
- Kristiina Vuori, M.D., Ph.D.
- Wilma M. Wasco, Ph.D.
- Philip B. Wedegaertner, Ph.D.
- Yixian Zheng, Ph.D.