William C. Sha, M.D., Ph.D.
![](/-/media/legacy/legacy-and-pre-launch-image-edits/scholars/1997/william-sha.jpg?la=es&h=168&w=156&hash=402E1A905BDC317E526A1350AB97BF14)
- Title
- Associate Professor of Immunology and Pathogenesis
- Department
- Department of Molecular & Cell Biology
- Institution
- University of California, Berkeley
- Address
- 142 Life Sciences Addition #3200
- City, State, ZIP
- Berkeley, CA 94720
- Phone
- (510) 643-2783
- [email protected]
- Website
- http://mcb.berkeley.edu/index.php?option=com_mcbfaculty&name=shab
- Research field
- Immunology
- Award year
- 1997
Research
We are interested in understanding the molecular control of antibody responses by B cells. We previously identified a novel costimulatory molecule, B7h, expressed on B cells and other antigen-presenting cells that is the sole in vivo ligand for the ICOS costimulatory receptor expressed on activated T cells. B7h is highly regulated and appears to be a critical control point on B cells for controlling the magnitude of antibody responses. We have identified two potent mechanisms, ectodomain shedding and transcriptional regulation, that severely limit B7h expression on activated B cells. We are currently studying how these molecular mechanisms are regulated and control antibody responses using both in vitro tissue culture assays and transgenic/knockout mouse models.
Scholar Keywords
1997 Search Pew Scholars
- Andrew Camilli, Ph.D.
- Ann Marie Craig, Ph.D.
- Patrick Dolph, Ph.D.
- Anirvan Ghosh, Ph.D.
- Benjamin S. Glick, Ph.D.
- Roberta A. Gottlieb, M.D.
- Gregory J. Hannon, Ph.D.
- Xi He, Ph.D.
- Ann B. Hill, Ph.D.
- Gokhan S. Hotamisligil, M.D., Ph.D.
- Gail P. Jarvik, M.D., Ph.D.
- Stephen L. Johnson, Ph.D.
- Maurice J. Kernan, Ph.D.
- Daniel S. Kessler, Ph.D.
- Michael R. Koelle, Ph.D.
- Kuo-Fen Lee, Ph.D.
- Tom W. Muir, Ph.D.
- William C. Sha, M.D., Ph.D.
- Kristiina Vuori, M.D., Ph.D.
- Wilma M. Wasco, Ph.D.
- Philip B. Wedegaertner, Ph.D.
- Yixian Zheng, Ph.D.