Saskia B. Neher, Ph.D.
![](/-/media/post-launch-images/2018/08/biomed-2018-resize/saskia-neher.jpg?la=es&h=250&w=250&hash=1EE908738358C93C925543F9E536FFE2)
- Title
- Assistant Professor
- Department
- Department of Biochemistry and Biophysics
- Institution
- University of North Carolina at Chapel Hill
- Address
-
120 Mason Farm Rd.
CB 7260 - City, State, ZIP
- Chapel Hill, NC 27599
- Phone
- (919) 966-9550
- [email protected]
- Website
- http://neherlab.web.unc.edu/
- Research field
- Biochemistry
- Award year
- 2012
Research
Research in my lab focuses on understanding the molecular mechanisms responsible for regulation of lipase activity. We aim to uncover how a transmembrane maturation factor assists in proper folding and ER exit of a group of dimeric mammalian lipases. We also study secreted proteins that regulate lipase activity in response to changes in nutritional state. Our research has biomedical relevance because biochemical deficiencies in lipase activity can cause hypertriglyceridemia, which is associated with increased risk for atherosclerosis. Our approach is interdisciplinary and uses membrane protein biochemistry, enzymology, and structural biology to understand lipase structure-function relationships.
Scholar Keywords
2012 Search Pew Scholars
- Dinu F. Albeanu, Ph.D.
- Peter V. Cornish, Ph.D.
- Maximiliano A. D'Angelo, Ph.D.
- David A. Drummond, Ph.D.
- Nels C. Elde, Ph.D.
- Donald Fox, Ph.D.
- Robert C. Froemke, Ph.D.
- Wolfram Goessling, M.D., Ph.D.
- Xue Han, Ph.D.
- Salil A. Lachke, Ph.D.
- Saskia B. Neher, Ph.D.
- Lorin E. Olson, Ph.D.
- Kevin K. Park, Ph.D.
- Sohini Ramachandran, Ph.D.
- Vanessa Ruta, Ph.D.
- Aimee Shen, Ph.D.
- Alexander Sher, Ph.D.
- Alexander V. Statsyuk, Ph.D.
- Kathryn E. Wellen, Ph.D.
- Mee-Ngan F. Yap, Ph.D.
- Wenjun Zhang, Ph.D.