David A. Drummond, Ph.D.
- Title
- Assistant Professor
- Department
- Department of Biochemistry and Molecular Biology
- Institution
- University of Chicago
- Address
-
929 E 57th St
GCIS W234 - City, State, ZIP
- Chicago, IL 60637
- Phone
- (773) 834-2017
- [email protected]
- Website
- http://drummond.openwetware.org/
- Research field
- Biochemistry; Molecular Biology
- Award year
- 2012
Research
What are the spectrum, frequency and consequences of errors in protein synthesis? How do cells sense and respond to misfolded proteins, particularly in the eukaryotic cytosol? How does stochasticity in protein synthesis alter the composition and stability of the proteome?
What benefits do errors confer? Does error-induced protein misfolding influence the progression of neurodegenerative diseases such as ALS?
We are pursuing mechanistic answers to these questions, taking a biochemical and genetic approach, with an emphasis on developing high-resolution, high-mass-accuracy mass spectrometric techniques for proteome-scale quantitation. From a theoretical standpoint, we are interested in understanding the imprints that natural selection on fidelity and misfolding leave on evolving genes and genomes.
Scholar Keywords
2012 Search Pew Scholars
- Dinu F. Albeanu, Ph.D.
- Peter V. Cornish, Ph.D.
- Maximiliano A. D'Angelo, Ph.D.
- David A. Drummond, Ph.D.
- Nels C. Elde, Ph.D.
- Don Fox, Ph.D.
- Robert C. Froemke, Ph.D.
- Wolfram Goessling, M.D., Ph.D.
- Xue Han, Ph.D.
- Salil A. Lachke, Ph.D.
- Saskia B. Neher, Ph.D.
- Lorin E. Olson, Ph.D.
- Kevin K. Park, Ph.D.
- Sohini Ramachandran, Ph.D.
- Vanessa Ruta, Ph.D.
- Aimee Shen, Ph.D.
- Alexander Sher, Ph.D.
- Alexander V. Statsyuk, Ph.D.
- Kathryn E. Wellen, Ph.D.
- Mee-Ngan F. Yap, Ph.D.
- Wenjun Zhang, Ph.D.