Lorin E. Olson, Ph.D.
- Title
- Assistant Member
- Department
- Department of Immunobiology and Cancer Research
- Institution
- Oklahoma Medical Research Foundation
- Address
- 825 N.E. 13th Street, MS 17
- City, State, ZIP
- Oklahoma City, OK 73104
- Phone
- (405) 271-7535
- [email protected]
- Website
- http://omrf.org/research-faculty/scientists/olson-lorin/
- Research field
- Developmental Biology
- Award year
- 2012
Research
Our laboratory is interested in understanding how wound repair and scar formation are regulated at the cellular and molecular level. All organisms have a robust wound repair response involving the generation of new tissue and extracellular matrix to replace what was damaged or lost. However, diseases such as atherosclerosis and fibrosis resemble wound repair gone wrong. We approach this question by studying genetically modified mice with alterations in platelet-derived growth factor (PDGF) signaling. PDGF signaling regulates the conversion of quiescent vascular cells and fibroblasts into activated, matrix-producing cells. Thus, it is important for normal wound repair and has been implicated in several chronic inflammatory diseases. We are using a combination of tissue-specific mutation, genetic background alteration, and lineage tracing to understand how scar formation occurs in disease and how it might be modulated to control disease.
Scholar Keywords
2012 Search Pew Scholars
- Dinu F. Albeanu, Ph.D.
- Peter V. Cornish, Ph.D.
- Maximiliano A. D'Angelo, Ph.D.
- David A. Drummond, Ph.D.
- Nels C. Elde, Ph.D.
- Don Fox, Ph.D.
- Robert C. Froemke, Ph.D.
- Wolfram Goessling, M.D., Ph.D.
- Xue Han, Ph.D.
- Salil A. Lachke, Ph.D.
- Saskia B. Neher, Ph.D.
- Lorin E. Olson, Ph.D.
- Kevin K. Park, Ph.D.
- Sohini Ramachandran, Ph.D.
- Vanessa Ruta, Ph.D.
- Aimee Shen, Ph.D.
- Alexander Sher, Ph.D.
- Alexander V. Statsyuk, Ph.D.
- Kathryn E. Wellen, Ph.D.
- Mee-Ngan F. Yap, Ph.D.
- Wenjun Zhang, Ph.D.