Enfu Hui, Ph.D.
- Title
- Assistant Professor
- Department
- Cell and Developmental Biology
- Institution
- University of California, San Diego
- Address
- 9500 Gilman Drive, 2222A Pacific Hall, Mail Code 0347
- City, State, ZIP
- La Jolla, CA 92093
- Phone
- (858) 246-0832
- [email protected]
- Website
- https://enfuhui.wixsite.com/huilab-ucsd
- Research field
- Immunology
- Award year
- 2018
Research
The Hui lab will dissect the mechanism by which the immune system can be exploited to eradicate cancers. Some tumor cells evade immune detection by binding to PD-1—a receptor that keeps immune cells switched off; drugs that block PD-1 have recently shown promise in treating these cancers. As a postdoctoral fellow, I discovered that PD-1 suppresses immune cell activity by blocking the activation of a stimulatory receptor called CD28. Now, our lab will determine whether and how additional immune “checkpoints” operate in conjunction with PD-1 to block CD28 or other immune receptors, and we will identify the inhibitory molecules these systems recruit to dampen the immune response. Our findings could lead to the development of novel immunotherapeutic agents and could hold the key to treating patients who develop a resistance to inhibitors of PD-1.
Scholar Keywords
2018 Search Pew Scholars
- Gregory M. Alushin, Ph.D.
- Megan T. Baldridge, M.D., Ph.D.
- Anna Beaudin, Ph.D.
- Adrienne A. Boire, M.D., Ph.D.
- Ilana L. Brito, Ph.D.
- Angela N. Brooks, Ph.D.
- Matthew Daugherty, Ph.D.
- Enfu Hui, Ph.D.
- John J. Karijolich, Ph.D.
- Hiroyuki Kato, Ph.D.
- Amy S.Y. Lee, Ph.D.
- Nuo Li, Ph.D.
- Aashish Manglik, M.D., Ph.D.
- Saket Navlakha, Ph.D.
- Hosea Nelson, Ph.D.
- Kassandra Ori-McKenney, Ph.D.
- Seth Rakoff-Nahoum, M.D., Ph.D.
- Tiffany A. Reese, Ph.D.
- Hesper Rego, Ph.D.
- Erin L. Rich, M.D., Ph.D.
- José A. Rodriguez, Ph.D.
- Paul A. Sigala, Ph.D.