Lei S. Qi, Ph.D.
- Title
- Assistant Professor
- Department
- Department of Bioengineering
- Institution
- Stanford University
- Address
-
443 Via Ortega
Shriram Center Room 329 - City, State, ZIP
- Stanford, CA 94305
- Phone
- (510) 520-8281
- [email protected]
- Website
- https://med.stanford.edu/profiles/stanleyqi
- Research field
- Bioengineering
- Award year
- 2016
Research
My lab is developing new approaches for programming immune cells to recognize and destroy tumors. A major hallmark of cancer cells is their extraordinary ability to evade detection and elimination by the immune system. For example, many cancer cells coat themselves in a protein called CD47, which, when encountered by immune cells, shuts down their defense mechanism—thus protecting the malignant cells from getting destroyed. Combining protein and genome engineering, I will generate enhanced immune cells with a special protein that, when encountered by CD47 on a cancer cell, creates a signal to switch immune defenses on, allowing the immune cell to engulf and kill the cancer cell. Notably, this system can be customized to recognize cancer-specific markers for diverse tumor types and to activate different kinds of immune responses. The work represents a novel method for designing and manufacturing cell-based immunotherapies against a variety of human cancers.
Scholar Keywords
2016 Search Pew Scholars
- Christopher D.C. Allen, Ph.D.
- Kristian G. Andersen, Ph.D.
- Martha W. Bagnall, Ph.D.
- Trevor Bedford, Ph.D.
- Donita C. Brady, Ph.D.
- Gloria A. Brar, Ph.D.
- Marco Gallio, Ph.D.
- Wendy R. Gordon, Ph.D.
- Jun R. Huh, Ph.D.
- Lauren Parker Jackson, Ph.D.
- Roozbeh Kiani, M.D., Ph.D.
- Peter W. Lewis, Ph.D.
- Dengke K. Ma, Ph.D.
- Eyleen J. O'Rourke, Ph.D.
- Nitin Phadnis, Ph.D.
- Maksim V. Plikus, Ph.D.
- Lei S. Qi, Ph.D.
- Katherine S. Ralston, Ph.D.
- Dragana Rogulja, Ph.D.
- Mikhail G. Shapiro, Ph.D.
- Radhika Subramanian, Ph.D.
- Michael M. Yartsev, Ph.D.