Thomas G. Fazzio, Ph.D.
![](/-/media/legacy/legacy-and-pre-launch-image-edits/scholars/2011/thomas-fazzio.jpg?la=es&h=1280&w=1151&hash=6B997C3E8C888405E1A1A21446C01AA0)
- Title
- Assistant Professor
- Department
- Program in Gene Function and Expression
- Institution
- University of Massachusetts Medical School
- Address
-
364 Plantation Street
LRB 519 - City, State, ZIP
- Worcester, MA 1605
- Phone
- (508) 856-6014
- [email protected]
- Website
- http://profiles.umassmed.edu/Profiles/display/130158
- Research field
- Stem Cell Biology; Genetics
- Award year
- 2011
Research
We are interested in the roles of chromatin remodeling proteins in regulation of embryonic stem (ES) cell identity. While a number of transcription factors that promote ES cell self-renewal (continued proliferation as stem cells) or differentiation are known, the mechanisms by which they regulate their gene targets are mysterious. Likewise, a number of chromatin regulators are important for ES cell self-renewal or differentiation, but their functions and genomic targets are poorly understood. We are taking genetic, genomic, biochemical and molecular approaches to study the roles of chromatin remodeling proteins in ES cells. These studies should lead to a greater understanding of how chromatin regulators interface with ES cell transcription factors to maintain the transcriptome, which should ultimately pave the way for the development of ES cell-based therapies for degenerative diseases.
Scholar Keywords
2011 Search Pew Scholars
- Christine M. Dunham, Ph.D.
- Thomas G. Fazzio, Ph.D.
- Max L. Fletcher, Ph.D.
- Hunter B. Fraser, Ph.D.
- Melissa K. Gardner, Ph.D.
- Mary Gehring, Ph.D.
- Jeff Gore, Ph.D.
- Takaki Komiyama, Ph.D.
- Mei Kong, Ph.D.
- Michael S. Kuhns, Ph.D.
- Erica Larschan, Ph.D.
- Eros Lazzerini Denchi, Ph.D.
- Ann C. Morris, Ph.D.
- James B. Moseley, Ph.D.
- Suzanne M. Noble, M.D., Ph.D.
- Brad J. Nolen, Ph.D.
- Chad G. Pearson, Ph.D.
- Sharad Ramanathan, Ph.D.
- Anthony R. Richardson, Ph.D.
- Niels Ringstad, Ph.D.
- Georgios Skiniotis, Ph.D.
- Liang Zhou, M.D., Ph.D.