Francis I. Valiyaveetil, Ph.D.
- Title
- Assistant Professor
- Department
- Department of Physiology and Pharmacology
- Institution
- Oregon Health and Science University
- Address
-
3181 SW Sam Jackson Park Road
Mail Code L334 - City, State, ZIP
- Portland, OR 97239
- Phone
- (503) 418-0946
- [email protected]
- Website
- http://www.ohsu.edu/xd/education/schools/school-of-medicine/departments/basic-science-departments/physpharm/faculty-staff/valiyaveetil.cfm
- Research field
- Biochemistry
- Award year
- 2007
Research
We study K+ channels, which are integral membrane proteins that catalyze the selective conduction of K+ ions across biological membranes. While a great deal of research has been focused on these channels, fundamental questions regarding the mechanism of ionic selectivity and gating remain. We have developed a unique combination of methods to address these questions. Our methods include the use of chemical synthesis to introduce precise chemical changes in the channels, x-ray crystallography to determine the structural effects and electrophysiology to determine the functional effects of these changes. Using this multidisciplinary approach we are presently investigating the mechanism of K+ selectivity and the process of slow inactivation.
Scholar Keywords
2007 Search Pew Scholars
- Gro V. Amdam, Ph.D.
- Kristin K. Baldwin, Ph.D.
- Robert H. Blelloch, M.D., Ph.D.
- Hinrich Boeger, Ph.D.
- Edward B. Brown, Ph.D.
- Ananda W. Goldrath, Ph.D.
- Ekaterina Heldwein, Ph.D.
- Deborah T. Hung, M.D., Ph.D.
- Bart Krekelberg, Ph.D.
- Michelle Krogsgaard, Ph.D.
- Joanna Masel, D.Phil.
- Craig A. Micchelli, Ph.D.
- Peter J. Mohler, Ph.D.
- Daniela Nicastro, Ph.D.
- Julie K. Pfeiffer, Ph.D.
- Michael P. Rape, Ph.D.
- Thomas U. Schwartz, Ph.D.
- David R. Sherwood, Ph.D.
- Francis I. Valiyaveetil, Ph.D.
- X.Z. Shawn Xu, Ph.D.