Jens Lykke-Andersen, M.S., Ph.D.
- Title
- Professor
- Department
- Division of Biological Sciences
- Institution
- University of California, San Diego
- Address
- 9500 Gilman Drive # 0322
- City, State, ZIP
- La Jolla, CA 92093-0322
- Phone
- (858)822-3659
- [email protected]
- Website
- http://www.biology.ucsd.edu/labs/lykkeandersen/
- Research field
- Genetics
- Award year
- 2003
Research
Our laboratory focuses on several aspects of mRNA decay regulation in human cells: 1) Regulation of ARE-mediated mRNA decay: To understand how the TTP-family of ARE-binding proteins activate mRNA decay, we are investigating how they communicate with enzymes involved in mRNA decay. 2) The mechanism of Nonsense-Mediated Decay: We are currently conducting experiments to understand how the EJC communicates with the hUpf proteins and the terminating ribosome. 3) Deadenylation in human mRNA decay: We are currently trying to establish the role of the deadenylases in the ARE- and nonsense-mediated decay pathways. 4) Decapping in human mRNA decay: We identified a human decapping complex that contains at least two proteins, hDcp1 and hDcp2, and we showed that the hDcp2 protein possesses catalytic activity. We affinity purified the decapping complex from a human cell line, and identified three new proteins in the complex. We are currently testing the importance of these novel proteins in mRNA decapping and decay.
Scholar Keywords
2003 Search Pew Scholars
- Peter Baumann, Ph.D.
- Pablo E. Castillo, M.D., Ph.D.
- Jue Chen, Ph.D.
- David K. Cortez, Ph.D.
- Laurent Coscoy, Ph.D.
- Richard I. Dorsky, Ph.D.
- Wei Guo, Ph.D.
- Henry N. Higgs, Ph.D.
- Timothy E. Holy, Ph.D.
- Kyonsoo Hong, Ph.D.
- Christine Jacobs-Wagner, Ph.D.
- Prasad V. Jallepalli, M.D., Ph.D.
- A. Wali Karzai, Ph.D.
- Jens Lykke-Andersen, M.S., Ph.D.
- D. Branch Moody, M.D.
- Karen F. Oegema, Ph.D.
- Roland P. Riek, Ph.D.
- Tricia R. Serio, Ph.D.
- Ambro van Hoof, Ph.D.