Barbara Panning, Ph.D.
![](/-/media/legacy/legacy-and-pre-launch-image-edits/scholars/2002/barbara-panning.jpg?la=es&h=150&w=150&hash=C509C63AE9517B1627C1AB9E9A84CDD3)
- Title
- Associate Professor
- Department
- Department of Biochemistry & Biophysics
- Institution
- University of California, San Francisco
- Address
-
Genentech Hall, S372B
600 16th Street - City, State, ZIP
- San Francisco, CA 94158
- Phone
- (415) 672-1304
- [email protected]
- Website
- http://profiles.ucsf.edu/barbara.panning
- Research field
- Biochemistry
- Award year
- 2002
Research
X chromosome inactivation is among the most fascinating examples of epigenetic regulation of gene expression. The transcriptional repression of one X chromosome in female somatic cells equalizes X-linked gene dosage between females and males. The Xist gene is crucial to initiate the X chromosome-wide alteration in chromatin structure that is restricted to one of two otherwise equivalent X chromosomes. The work in my lab is aimed at understanding three fundamentally important aspects of X-inactivation. How does Xist RNA function to alter chromatin structure? How is Xist developmentally regulated? And, how is a two-fold (or more) difference in X chromosome number sensed by the cell to restrict X-inactivation to cells with multiple X chromosomes?
Scholar Keywords
2002 Search Pew Scholars
- Sharon L. Amacher, Ph.D.
- Carsten G. Bönnemann, M.D.
- Chavela M. Carr, Ph.D.
- Arul M. Chinnaiyan, M.D., Ph.D.
- James J. DiCarlo, M.D., Ph.D.
- Steven A. Farber, Ph.D.
- Michael A. Farrar, Ph.D.
- Z. Josh Huang, Ph.D.
- Tarun M. Kapoor, Ph.D.
- Michael Lagunoff, Ph.D.
- Ralf Langen, Ph.D.
- Barbara Panning, Ph.D.
- C.S. Raman, Ph.D.
- Karin M. Reinisch, Ph.D.
- Nina R. Salama, Ph.D.
- Dietmar Schmucker, Ph.D.
- Brenda A. Schulman, Ph.D.
- Ralph Scully, M.B.B.S., Ph.D.
- Jason D. Weber, Ph.D.
- Yong-Rui Zou, Ph.D.