Mark D. Fleming, M.D., D.Phil.
- Title
- Professor and Chairman
- Department
- Pathology
- Institution
- Boston Children's Hospital, Harvard University
- Address
-
CHB 3027
300 Longwood Avenue - City, State, ZIP
- Boston, MA 02115
- Phone
- (617) 919-2665
- [email protected]
- Website
- http://www.childrenshospital.org/researchers/mark-fleming
- Research field
- Genetics
- Award year
- 2000
Research
My research is focused on determining how erythroid cells acquire and utilize iron. Researchers in my lab are pursuing two general approaches: 1) Postionally cloning and characterizing the genes underlying several mouse hereditary defects in erythroid iron metabolism. 2) Using targeted mutagenesis in the mouse to study proteins implicated in the pathogenesis in a group of bone marrow disorders known as sideroblastic anemias. In those disorders, erythroid precursors develop pathologic iron deposits in mitochondria, which play a unique role in metabolizing iron and heme. We are seeking to characterize proteins responsible for mitochondrial iron import and utilization.
Scholar Keywords
2000 Search Pew Scholars
- Michael J. Berry II, Ph.D.
- Sylvie Doublié, Ph.D.
- Mark D. Fleming, M.D., D.Phil.
- Barbara L. Golden, Ph.D.
- Bob Goldstein, Ph.D.
- Dorit Hanein, Ph.D.
- Jay D. Horton, M.D.
- Dean H. Kedes, M.D., Ph.D.
- Caroline F. Kisker, Ph.D.
- Qiufu Ma, Ph.D.
- Pamela B. Meluh, Ph.D.
- R. Dyche Mullins, Ph.D.
- Venkatesh N. Murthy, Ph.D.
- George A. O'Toole, Ph.D.
- David J. Sullivan, M.D.
- Lise R. Thomas, Ph.D.
- Mark B. Van Doren, Ph.D.
- Thomas E. Wilson, M.D., Ph.D.
- Hao Wu, Ph.D.
- Phillip D. Zamore, Ph.D.