Prasad V. Jallepalli, M.D., Ph.D.
![](/-/media/legacy/legacy-and-pre-launch-image-edits/scholars/2003/prasad-jallepalli.jpg?la=pl&h=124&w=150&hash=873E93B5EA16F2DEB5221CB5156A26BB)
- Title
- Member and Professor
- Department
- Molecular Biology Program
- Institution
- Memorial Sloan Kettering Cancer Center
- Address
-
1275 York Avenue
Box 97 (RRL 1101E) - City, State, ZIP
- New York, NY 10065
- Phone
- (212) 639-3252
- [email protected]
- Website
- http://www.mskcc.org/research/lab/prasad-jallepalli
- Research field
- Molecular Biology
- Award year
- 2003
Research
In the vast majority of solid tumors, genomic instability manifests itself as gross structural and numerical abnormalities affecting chromosomes. This phenotype, termed chromosomal instability (CIN), accounts for the aneuploidy and chromosomal rearrangements found in virtually all cancer cells at the cytogenetic level. Our lab is broadly interested in the mechanisms that control the fidelity of chromosome transmission in human cells, which we suspect may be disrupted in some CIN cancers. To do this, we exploit novel methods that we recently developed to delete genes in cultured human cells. We can thus rapidly generate isogenic cell lines in which a particular gene has been ‘knocked out,’ either constitutively or conditionally.
Scholar Keywords
2003 Search Pew Scholars
- Peter Baumann, Ph.D.
- Pablo E. Castillo, M.D., Ph.D.
- Jue Chen, Ph.D.
- David K. Cortez, Ph.D.
- Laurent Coscoy, Ph.D.
- Richard I. Dorsky, Ph.D.
- Wei Guo, Ph.D.
- Henry N. Higgs, Ph.D.
- Timothy E. Holy, Ph.D.
- Kyonsoo Hong, Ph.D.
- Christine Jacobs-Wagner, Ph.D.
- Prasad V. Jallepalli, M.D., Ph.D.
- A. Wali Karzai, Ph.D.
- Jens Lykke-Andersen, M.S., Ph.D.
- D. Branch Moody, M.D.
- Karen F. Oegema, Ph.D.
- Roland P. Riek, Ph.D.
- Tricia R. Serio, Ph.D.
- Ambro van Hoof, Ph.D.