Joseph R. Pomerening, Ph.D.

Research

We study how the many stages required for cellular mitosis are regulated. Our research takes advantage of single-cell approaches along with cell sorting and live cell imaging of mammalian cells. We are investigating the role of cyclin-dependent kinases, proteins that modify other proteins to alter their expression, allowing for dynamic changes that ultimately direct the cell to progress in mitosis until it is complete. We aim to merge both experimental and computations methods to create a big picture, quantitative model of how kinase activity impacts cellular mitosis, to increase our understanding of certain disease models with aberrant cell cycling progression such as cancer.