Graciela L. Lorca, Ph.D.

Research

We are interested in the chemical biology of one-component transcriptional regulators (TF). They are involved in the regulation of the gene expression in response to a wide variety of intracellular and environmental signals. My lab is particularly interested in the identification of those small signal molecules using high throughput screening of small molecule libraries, and in how the small molecule/TF interactions can be modified/optimized. We are exploring the possibility of using new regulatory networks for the in vivo delivery of bioactive molecules using Lactobacillus as live vector.